Table 2. Coding missense changes found in the APC, CTNNB1, and AXIN1 genes in patients with multiple adenomatous polyps and controls.

Gene	Exon	GenBank accession no.	Nucleotide position	Codon	Allele 1	Allele 2	Mutation	No. of patients	No. of controls	Reference
APC	15	NM42_000038	3949	1317	GAA	CAA	E1317Q	3	6/480	3, 4
CTNNB1	6	NM42_001904	1074	287	AAC	AGC	N287S	1	3/483	21*
AXIN1	2	AF009674	899	312	CCC	ACC	P312T	1	0/481	This work
AXIN1	4	AF009674	1158	398	CGT	CAT	R398H	1	0/481	This work
AXIN1	5	AF009674	1186	445	CTG	ATG	L445M	1	0/483	19*
AXIN1	6	AF009674	1600	545	GAC	GAG	D545E	2	6/469	36
AXIN1	7	AF009674	2063	700	GGC	AGC	G700S	6	19/480	38
AXIN1	10	AF009674	2637	891	CGA	CAA	R891Q	7	14/478	36

The number of patients tested in each case was 124, whereas the number of controls with definitive results varied from 469 to 483 as indicated. Allele 1 is the common allele, and Allele 2 is the variant. The altered nucleotide giving rise to the variant allele is underlined.

^*Reference refers to report of somatic, not germ-line, change.