Table 2. Expression of Glial Markers in the Hippocampus Presented as Fold Increase from LF mice.
(post-hoc test: Bolded black, P< 0.05 compared to LF and HSV-LF, but not HSV-HF; Green P< 0.05 compared to LF, HSV-LF, and HSV-HF; Blue P< 0.05 compared to LF, HSV-LF).
| Gene | LF | HSV-LF | HF | HSV-HF | Pdiet | Pinfection | Pdietxinfection |
|---|---|---|---|---|---|---|---|
| Markers of Primed Glia | |||||||
| TLR4 | 1.00±0.12 | 0.97±0.23 | 1.09±0.17 | 1.80±0.16 | 0.02 | 0.08 | 0.06 |
| MHCII | 1.00±0.08 | 1.12±0.14 | 1.74±0.30 | 1.80±0.20 | 0.00 | 0.58 | 0.95 |
| CD80 | 1.00±0.16 | 0.89±0.20 | 1.29±0.21 | 1.96±0.28 | 0.01 | 0.24 | 0.11 |
| CD86 | 1.00±0.18 | 0.85±0.25 | 1.26±0.21 | 2.08±0.34 | 0.02 | 0.24 | 0.10 |
| CD11b | 1.00±0.05 | 1.06±0.16 | 1.41±0.29 | 2.18±0.30 | 0.01 | 0.10 | 0.16 |
| Cytokines Released by Activated Glia | |||||||
| IL-1β | 1.00±0.15 | 1.18±0.18 | 1.40±0.24 | 2.50±0.46 | 0.02 | 0.06 | 0.17 |
| IL-6 | 1.00±0.26 | 1.45±0.65 | 1.26±0.40 | 3.62±1.67 | 0.31 | 0.25 | 0.04 |
| TNFα | 1.00±0.08 | 0.87±0.13 | 1.42±0.25 | 1.52±0.18 | 0.01 | 0.93 | 0.53 |
| IL-10 | 1.00±0.39 | 1.03±0.13 | 3.06±0.61 | 2.70±0.89 | 0.01 | 0.80 | 0.76 |