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Squamous cell carcinoma of the anus: superficial epithelium with severe dysplasia is evident in the upper right of the image, whereas infiltrative carcinoma can be observed in the lower right. Normal intestinal glands are evident on the left (A: hematoxylin and eosin; B: in situ hybridization for HR-HPV detection). HR-HPV = high-risk human papillomavirus.
