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Schematic drawing of types of molecular alterations observed in imprinting disorders and their effect on DNA methylation at imprinting control regions (ICRs) in a scenario when methylation occurs on the maternal allele. The paternal chromosome is shown in light gray, and the maternal chromosome is shown in dark gray. M- is DNA methylation at the ICR. Imprinting defect can result either from idiopathic DNA methylation change or microdeletion/microduplication at ICR.
