Table 1. Analysis of SHM at the IgVH4–34 gene of control and Pol μ-overproducing Ramos cells.
Control Ramos | Pol μ-overproducing Ramos | |
---|---|---|
Mutations | 32 | 111 |
Total nt sequenced | 27 962 | 34 782 |
Mutational frequency (×10−3 × Mut × base−1) | 1.1 | 3.2 |
A/T mutated | 21.9 | 3.6 |
G/C mutated | 78.1 | 96.4 |
Ts/Tv | 0.46 | 0.75 |