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The apparent half maximum effects (EC50) of leptin on indices of energy metabolism (A) and bone formation (B). Depending on endpoint measured, the half maximum effects of leptin on indices of energy metabolism were detected at dose rates of 40–80 ng/h whereas the half maximum effects of leptin on indices of bone formation were detected at dose rates of 7–25 ng/h. The vertical dotted lines indicate the range in EC50.
