Table 1.

Hypothalamus Jak/Stat signaling array showing significant changes for genes in ob/ob mice administered 12 ng/h or 140 ng/h leptin compared to ob/ob mice administered vehicle (0 ng/h leptin).

Differentially Expressed Genes
ob/ob+12 ng/h leptin vs. ob/ob+veh (n=3 genes)			ob/ob+140 ng/h leptin vs. ob/ob+veh (n=23 genes)
Symbol	Fold Change	P <	Symbol	Fold Change	P <
Crk	−1.1	0.048	Bcl2l1	−1.2	0.009
Ghr	−1.3	0.020	Cdkn1a	−1.7	0.002
Stam	−1.2	0.029	Cebpb	−1.7	0.003
			Cebpd	−1.7	0.023
			Egfr	−1.3	0.019
			Fas	−1.3	0.010
			Fcer2a	−1.4	0.005
			Ghr	−1.5	0.002
			Il2ra	−1.7	0.041
			Insr	−1.5	0.006
			Mpl	−1.9	0.015
			Nos2	−1.4	0.017
			Nr3c1	−1.2	0.035
			Pias2	−1.2	0.038
			Prlr	−1.5	0.040
			Ptpn11	−1.5	0.010
			Smad1	−1.2	0.024
			Smad2	−1.2	0.039
			Smad5	−1.3	0.017
			Socs1	−1.4	0.020
			Sp1	−1.2	0.020
			Stam	−1.3	0.004
			Stat4	−2.1	0.001

N = 6, 5, and 5 mice in vehicle, 12 ng/h leptin, and 140 ng/h leptin group, respectively.