Table 2.

Tibia Jak/Stat signaling array showing signficant changes for genes in ob/ob mice administered 12 ng/h or 140 ng/h leptin compared to ob/ob mice administered vehicle (0 ng/h leptin).

Differentially Expressed Genes
ob/ob+12 ng/h leptin vs. ob/ob+veh (n=30 genes)			ob/ob+140 ng/h leptin vs. ob/ob+veh (n=52 genes)
Symbol	Fold Change	P <	Symbol	Fold Change	P <
A2m	2.4	0.000	A2m	6.4	0.002
Csf1r	1.1	0.040	Akt1	1.4	0.001
Cxcl9	1.6	0.011	Bcl2l1	−2.1	0.000
Epor	1.2	0.038	Crk	1.6	0.004
Fcgr1	1.4	0.001	Csf1r	1.2	0.014
Gata3	1.3	0.030	Epor	−1.9	0.000
Gbp2b	1.6	0.001	Fas	1.3	0.019
Ifnar1	1.3	0.000	Fcer2a	1.6	0.020
Ifngr1	1.1	0.048	Fcgr1	1.7	0.002
Il10ra	1.5	0.000	Gbp2b	1.6	0.002
Il2ra	2.6	0.000	Ifnar1	1.6	0.000
Il6st	1.1	0.019	Il10ra	2.5	0.000
Insr	1.2	0.028	Il10rb	1.2	0.023
Irf1	1.2	0.000	Il2ra	8.0	0.000
Irf9	1.2	0.006	Il2rg	1.4	0.004
Jak3	1.2	0.039	Il4	1.7	0.013
Mpl	−1.3	0.015	Il4ra	1.5	0.000
Nr3c1	1.2	0.002	Il6st	1.3	0.001
Oas1a	1.5	0.008	Irf1	1.8	0.000
Pdgfra	1.3	0.001	Irf9	1.3	0.021
Pias2	1.3	0.004	Isg15	−2.3	0.001
Ptprc	1.1	0.039	Jak2	−1.2	0.001
Sh2b2	1.1	0.040	Jak3	1.5	0.002
Smad3	1.3	0.017	Junb	1.4	0.030
Smad4	1.2	0.001	Mcl1	1.1	0.034
Smad5	1.2	0.001	Mpl	−1.3	0.029
Socs2	1.3	0.005	Myc	1.2	0.049
Socs5	1.2	0.022	Nfkb1	1.4	0.000
Stat1	1.2	0.003	Nr3c1	1.3	0.000
Stat2	1.2	0.002	Oas1a	2.1	0.001
			Osm	1.7	0.002
			Pdgfra	1.6	0.000
			Pias2	1.5	0.000
			Ptpn1	1.1	0.035
			Ptprc	1.3	0.011
			Spi1	1.3	0.000
			Sh2b1	1.3	0.006
			Sh2b2	1.2	0.018
			Smad1	1.2	0.004
			Smad2	1.1	0.040
			Smad3	1.3	0.003
			Smad4	1.4	0.000
			Smad5	1.4	0.002
			Socs2	1.3	0.000
			Socs5	1.7	0.007
			Stat1	1.5	0.002
			Stat2	1.6	0.000
			Stat3	1.3	0.000
			Stat5b	1.2	0.031
			Stat6	1.4	0.003
			Tyk2	1.2	0.031
			Usf1	1.3	0.001

N = 6, 5, and 5 mice in vehicle, 12 ng/h leptin, and 140 ng/h leptin group, respectively.