Table 3.

Hypothalamus neurotransmitter receptor array showing significant changes for genes in ob/ob mice administered 12 ng/h or 140 ng/h leptin compared to ob/ob mice administered vehicle (0 ng/h leptin).

Differentially Expressed Genes
ob/ob+12 ng/h leptin vs. ob/ob+veh (n=6 genes)			ob/ob+140 ng/h leptin vs. ob/ob+veh (n=61 genes)
Symbol	Fold Change	P <	Symbol	Fold Change	P <
Gabbr1	−1.1	0.047	Adra1a	−1.7	0.000
Gabbr2	1.3	0.009	Adra1d	6.4	0.002
Gabrb1	−1.2	0.018	Adra2a	−1.8	0.001
Gria2	−1.2	0.044	Adrb2	−1.7	0.005
Grin2a	−1.2	0.010	Avpr1a	−1.6	0.003
Grm5	−1.2	0.013	Avpr1b	5.5	0.002
			Brs3	4.5	0.003
			Chrm1	−1.4	0.019
			Chrm5	−1.9	0.000
			Chrna5	2.8	0.010
			Chrna6	−2.0	0.018
			Chrna7	−1.5	0.000
			Cnr1	−1.8	0.000
			Drd1a	−1.2	0.046
			Drd5	7.5	0.004
			Gabbr1	−1.5	0.000
			Gabra1	−1.7	0.020
			Gabra2	−1.9	0.006
			Gabra5	−1.6	0.001
			Gabrb1	−1.7	0.001
			Gabrb3	−1.4	0.000
			Gabrd	2.9	0.002
			Gabre	−1.8	0.001
			Gabrg1	−1.7	0.002
			Gabrg3	−2.0	0.001
			Gabrq	−1.5	0.004
			Gabrr1	−1.7	0.031
			Gria1	−1.7	0.002
			Gria2	−1.9	0.001
			Gria3	−1.7	0.003
			Grik1	−1.5	0.001
			Grik2	−1.8	0.000
			Grik4	−1.4	0.003
			Grik5	−1.3	0.017
			Grin1	−1.4	0.003
			Grin2a	−1.7	0.000
			Grin2b	−1.5	0.001
			Grin2c	−1.3	0.013
			Grm1	−1.5	0.001
			Grm5	−1.9	0.000
			Grm7	−1.6	0.001
			Grm8	−1.7	0.000
			Grpr	−2.2	0.000
			Hcrtr2	−1.7	0.003
			Hrh1	1.7	0.004
			Htr1a	1.3	0.018
			Htr1b	−1.8	0.003
			Htr1f	−1.8	0.003
			Htr2a	7.5	0.002
			Htr2b	−1.6	0.002
			Htr3a	−1.4	0.012
			Htr4	6.9	0.002
			Htr7	−1.5	0.000
			Ntsr2	−1.4	0.015
			Oxtr	−1.8	0.009
			Prokr2	−1.3	0.013
			Sstr1	−1.6	0.001
			Sstr2	1.3	0.033
			Sstr4	1.4	0.027
			Tacr1	−1.2	0.043
			Tacr3	−1.6	0.001

N = 6, 5, and 5 mice in vehicle, 12 ng/h leptin, and 140 ng/h leptin group, respectively.