Table 4.

Tibia osteoporosis array showing significant changes for genes in ob/ob mice administered 12 ng/h or 140 ng/h leptin compared to ob/ob mice administered vehicle (0 ng/h leptin).

Differentially Expressed Genes
ob/ob+12 ng/h leptin vs. ob/ob+veh (n=23 genes)			ob/ob+140 ng/h leptin vs. ob/ob+veh (n=35 genes)
Symbol	Fold Change	P <	Symbol	Fold Change	P <
Alox12	−1.2	0.019	Alox12	−1.3	0.042
Alpl	1.4	0.004	Alpl	1.7	0.001
Bglap	1.9	0.001	Bglap	3.0	0.000
Bmp7	1.2	0.009	Bmp7	1.3	0.012
Calcr	2.2	0.007	Calcr	2.2	0.017
Cd40	1.4	0.000	Car2	−3.8	0.000
Col1a1	1.5	0.015	Cd40	2.7	0.000
Col1a2	1.4	0.032	Cnr2	1.6	0.006
Crtap	1.1	0.030	Col1a1	1.7	0.011
Il6ra	−1.3	0.003	Col1a2	1.6	0.007
Lepre1	1.3	0.003	Comt	−1.4	0.002
Ltbp2	1.2	0.009	Dbp	1.8	0.002
Mmp2	1.4	0.012	Dkk1	1.3	0.038
Npy	1.5	0.025	Enpp1	−1.2	0.004
Nr3c1	1.2	0.018	Esr1	1.2	0.022
Plod2	1.4	0.009	Il15	1.4	0.019
Pth1r	1.3	0.003	Il6ra	−1.3	0.018
Sfrp4	1.4	0.002	Itga1	1.1	0.040
Sparc	1.4	0.010	Lepre1	1.5	0.000
Stat1	1.2	0.003	Lrp5	1.3	0.000
Timp2	1.1	0.033	Lrp6	1.2	0.014
Tnfaip3	1.3	0.030	Ltbp2	1.6	0.000
Twist1	1.2	0.027	Mmp2	1.4	0.017
			Mthfr	1.4	0.008
			Nfatc1	1.2	0.002
			Npy	1.5	0.044
			Nr3c1	1.3	0.000
			Plod2	1.5	0.010
			Pth1r	1.3	0.027
			Sfrp4	1.6	0.004
			Sparc	1.5	0.008
			Stat1	1.5	0.002
			Tnfaip3	1.3	0.006
			Tnfrsf11b	1.2	0.038
			Tnfrsf1b	1.6	0.001

N = 6, 5, and 5 mice in vehicle, 12 ng/h leptin, and 140 ng/h leptin group, respectively.