Table 4.

Predictors for adverse events during enalapril exposure.

	Hyperkalemiaa	Elevated Creatinineb	Hypotension	Composite Outcomec
Postnatal age, days
<30	2.47 (1.19–5.12)	11.1 (2.72–45.3)	15.6 (1.30–189)	4.85 (2.51–9.38)
30–60	1.77 (0.61–5.17)	4.05 (0.61–27.1)	3.08 (0.16–60.0)	2.21 (0.91–5.41)
61–120	Ref	Ref	Ref	Ref
Duration of exposure, days	1.08 (1.05–1.10)	1.00 (0.95–1.04)	0.97 (0.92–1.03)	1.06 (1.03–1.08)
Gestational age, weeks
<28	0.61 (0.26–1.41)	2.44 (0.81–7.37)	1.31 (0.29–5.88)	0.98 (0.48–1.97)
28–33	0.88 (0.43–1.78)	1.67 (0.66–4.26)	1.03 (0.37–2.86)	0.87 (0.48–1.60)
>33	Ref	Ref	Ref	Ref
Small for gestational age
Yes	0.98 (0.49–1.98)	1.51 (0.52–4.41)	1.01 (0.30–3.43)	1.33 (0.71–2.50)
Race/ethnicity
White	Ref	Ref	Ref	Ref
Black	3.12 (1.51–6.46)	1.67 (0.53–5.23)	0.24 (0.03–2.04)	1.60 (0.84–3.05)
Hispanic	1.02 (0.49–2.13)	1.89 (0.78–4.58)	0.98 (0.38–2.52)	1.33 (0.76–2.34)
Other	3.98 (1.34–11.8)	1.99 (0.36–11.0)	1.15 (0.26–5.14)	1.59 (0.56–4.55)
Sex
Male	1.37 (0.75–2.50)	0.76 (0.34–1.68)	1.22 (0.51–2.92)	1.16 (0.72–1.89)
5-minute Apgar score
0–3	1.59 (0.72–3.52)	1.10 (0.27–4.41)	0.99 (0.18–5.37)	1.74 (0.83–3.68)
4–6	0.86 (0.35–2.10)	0.59 (0.17–2.11)	1.63 (0.55–4.87)	0.94 (0.46–1.90)
7–10	Ref	Ref	Ref	Ref
Inborn
Yes	0.84 (0.46–1.55)	1.03 (0.43–2.47)	0.53 (0.23–1.21)	0.76 (0.45–1.26)

Data presented as odds ratio (95% confidence interval). Death during enalapril exposure was a rare outcome and regression could not be performed due to model overfitting.

^aRegression controlled for baseline potassium level prior to exposure.

^bRegression controlled for baseline creatinine level prior to exposure.

^cRegression controlled for baseline potassium and creatinine levels prior to exposure.