Figure 8. KLF4 suppresses lung tumor formation and hTERT expression in vivo.

(A) Tumor growth of KLF4-overexpressing H322 cells (H322/c2) and mock controls in nude mice. The tumor volume was calculated using the following equation: V = (width² × length)/2. *P < 0.05. (B) Representative tumor grafts are shown, which were grown in nude mice injected with H322/mock and H322/c2 cells. (C) The tumor weight was compared between the H322/mock and H322/c2 groups. (D) Representative images of KLF4 and hTERT staining are presented in each group of nude mice using immunhistochemistry analysis.