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. 2016 Jul 15;7(33):53137–53152. doi: 10.18632/oncotarget.10614

Figure 4. Sertraline targets BTIC ex vivo.

Figure 4

(A) Mouse mammary tumor derived cells exposed to sertraline in vitro under sphere-forming conditions yield tumors after transplant into syngeneic mice with reduced frequency and increased latency compared to vehicle-treated cells. The Kaplan-Meier curve comparisons were performed using the log-rank test; P = 0.0003. (B) Sertraline treated tumor cells formed tumors that grow more slowly in vivo after transplant than did those exposed to the vehicle. One-way ANOVA P = 0.02. (C) After 15 weeks tumors formed by sertraline-treated tumor cells (7.5 μM) are on average substantially smaller than those formed by vehicle treated tumor cells. P-value (*) < 0.05.