Figure 6. In combination sertraline and docetaxel inhibit tumor growth to a greater extent than either drug individually.

(A) Docetaxel and sertraline were administered on the first day of the treatment regimen, whereas thereafter sertraline was administered daily for another 4 consecutive days. No treatments were provided for 2 consecutive days after the 5-day treatment period. (B) Sertraline or docetaxel modestly inhibited tumor growth rate, but the combination of both drugs shrank tumors. (C) The combination of sertraline and docetaxel reduced final tumor volume to a much greater extent than did either drug individually. On-way ANOVA P < 0.0001.