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. 2016 Jul 20;7(33):53254–53268. doi: 10.18632/oncotarget.10736

Figure 2. miR-770-5p levels predict response to platinum-based chemotherapy and survival in OVC patients.

Figure 2

(A) Leave-one-out cross prediction of cisplatin responders (blue: CR, yellow: IR), n = 53. a 6.128 in expression was the cutoff value having the highest Youden's index; accuracy, sensitivity, and specificity were 81.1%, 80%, and 83% respectively. (B) Receiver operating characteristic (ROC) curve of the cisplatin responders. A Mann-Whitney U test demonstrated that miR-770-5p expression distinguished IR patients from CR patients (p < 0.001). Mean AUC is 0.849 (0.79–0.91). (C) Confirmation that the 6.128 cutoff predicted cisplatin response prediction as indicated by ROC curve analysis. (D) In 47 randomly selected OVC patients, overall survival was higher in those with high miR-770-5p expression (CR = 28, IR = 19; p < 0.05). (E–F). Overall survival of CR and IR patients divided into high and low miR-770-5p subgroups. Kaplan-Meier survival analysis also indicated that low miR-770-5p expression was associated with shorter overall survival compared to the high expression group (n = 25 for CR and n = 15 for IR, p < 0.001 for CR group, p < 0.05 for IR group). AUC: area under the curve.