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. 2016 Jul 20;7(33):53254–53268. doi: 10.18632/oncotarget.10736

Figure 3. Overexpression of miR-770-5p inhibits survival of chemo-resistant cell lines after cisplatin treatment.

Figure 3

(A) Transfection with pre-miR-770-5p inhibited survival in C13 and A2780CP cells treated with various concentrations of cisplatin compared to mock and negative control groups (n = 10 for all groups). (B) Viability decreased in C13 and A2780CP cells after different lengths (0 to 96 h) of miR-770-5p transfection compared to mock and negative control groups (C) Real-time RT-PCR confirmed the success of pre-miR-770-5p transfection. (D) Pre-miR-770-5p, negative control, and mock transfected cell lines (C13 and A2780CP) were cultured in media containing cisplatin. Cell numbers were counted after 48 hours of treatment. †, statistically significant difference in miR-770-5p expression compared to either negative control or mock-transfected cells (all p < 0.01).