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. 2016 Jul 11;7(33):53362–53376. doi: 10.18632/oncotarget.10523

Figure 2. Delineation of biopsy targets on mpMRI and fusion of targets on 3D TRUS.

Figure 2

A. Screenshots from ProFuse software (Eigen, Grass Valley, CA) for fusion of mpMRI delineated prostate Regions of Interest (ROIs) for targeted biopsy. Two axial slices, going from base (top) to apex (bottom) are displayed. The prostate volume is outlined (yellow contour); (Left) T2-weighted MRI; (Center) Apparent Diffusion Coefficient (ADC) derived from Diffusion Weighted Imaging (DWI); and (Right) Early enhancing image from Dynamic Contrast Enhanced (DCE-)MRI. The volumes in red, green and blue are assigned high, medium and low probability for cancer; B. A screenshot from Artemis (Eigen, Grass Valley, CA), displaying the 3D TRUS views corresponding to the axial slices in (A) after non-rigid fusion of the prostate boundaries on MRI and ultrasound. The targets are transferred from mpMRI to real-time ultrasound biopsy system; C. Schematic representation of the prostate and target volumes. (Note that the display contains a ROI in yellow is with unassigned probability). Yellow lines indicate biopsy needle tracks (1 needle in green, 2 in red and 1 in blue); The corresponding N&E slides at 20 x magnification from green target (left; Gleason Score 6) and red targets (right, Gleason Score 7).