Table 4. Log-rank test comparison of Kaplan-Meier survival analysis for the seven-miRNA signature vs. the “sevenminus- one” miRNA signatures in GBM patients.
| Training set (109) | Validation set | Independent set | |
|---|---|---|---|
| Disease Free Survival | |||
| 7-microRNA signature | <0.0001 | 0.0066 | 0.0016 |
| 5-microRNA signature minus | |||
| microRNA-124a | 0.036 | 0.124 | 0.059 |
| microRNA-129 | 0.018 | 0.0081 | 0.033 |
| microRNA-139 | 0.0098 | 0.01 | 0.058 |
| microRNA-21 | 0.025 | 0.0164 | 0.083 |
| microRNA-218 | 0.027 | 0.05 | 0.0043 |
| microRNA-15b | 0.072 | 0.004 | 0.0012 |
| microRNA-7 | 0.08 | 0.147 | 0.013 |
| Overall Survival | |||
| 7-microRNA signature | 0.0014 | 0.0091 | 0.0035 |
| 5-microRNA signature minus | |||
| microRNA-124a | 0.042 | 0.13 | 0.042 |
| microRNA-129 | 0.049 | 0.171 | 0.044 |
| microRNA-139 | 0.006 | 0.097 | 0.051 |
| microRNA-21 | 0.09 | 0.031 | 0.041 |
| microRNA-218 | 0.04 | 0.064 | 0.0102 |
| microRNA-15b | 0.12 | 0.018 | 0.023 |
| microRNA-7 | 0.101 | 0.073 | 0.037 |