Table 1A. Frameshift analysis of coding microsatellites in MLH1^-/- GI-derived tumors.

cMS Marker
Sample	APC	Tmem60	Senp6	Phactr4	Mdm2	Mdc1	Casc3	SDCCAG1	Rasal2	Tcf7l2	Bend5	NKtr1	Rfc3
# 1	wt	wt/-1	wt	-1	wt	wt/-1	wt	wt	wt	wt	wt	wt	wt/-1
# 2	wt/-1	wt/-1	wt	wt	wt	wt	wt/-1	wt	wt/-1	wt	wt/-1	wt	wt/-1
# 3	wt/-1	wt/-1	wt	-1	wt	wt/-1	wt	wt	wt	wt	wt	wt	wt/-1
# 4	wt/-1	wt	-1	wt	wt	wt	wt	wt	wt	wt	wt/-1	wt	wt/-1
# 5*	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt/-1
# 6	wt/-1	wt	wt/-1	wt	wt	wt	wt/-1	wt	wt/-1	wt	wt/-1	wt	wt/-1
# 7	wt	wt	wt/-1	wt/-1	wt	wt	wt	wt/-1	wt	wt	wt	wt	wt/-1
# 8	wt	wt/-1	wt	wt/-1	wt	wt	wt	wt	wt/-1	wt	wt	wt	wt/-1
# 9	wt	wt	wt	wt/-1	neg.	wt	wt	wt	wt/-1	wt	wt	wt/-1	wt/-1
# 10	wt	wt/-1	wt/-1	wt/-1	wt	wt	wt	wt	wt/-1	wt/-1	wt	wt	wt/-1
# 11§	wt	wt	wt/-1/-2	wt/-1	wt	wt	wt	wt	wt/-1	wt/-1	wt	wt	wt/-1
# 11+	wt	wt	wt/-1	wt	del	wt	wt	wt	wt/-1	wt/-1	wt	wt	wt/-1
# 12	wt	wt/-1	wt/-1	wt/+1	wt	wt	wt	wt	wt/-1	wt	wt	wt	wt/-1
# 13	wt	wt	wt/-1	wt	wt	wt	wt	wt	wt/-1	wt	wt	wt	wt/-1
# 14	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt/-1
# 15	wt/-1	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt/-1
# 16	wt	wt	wt	wt/-1	wt	wt	wt	wt/+1	wt	wt	wt	wt	wt/-1
# 17	wt/-1	wt	wt	wt/-1	wt	wt	wt	wt	wt	wt	wt	wt	wt/-1
# 18	wt	wt	wt/-1	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt/-1
# 19	wt/-1	wt	wt	-1	wt	wt	wt/-1	wt	wt	wt	wt	wt	wt/-1
# 20	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt	wt/-1
frequency [n]	7/21	6/21	9/21	11/21	2/21	2/21	3/21	2/21	9/21	3/21	3/21	1/21	21/21
frequency [%]	33.3	28.6	42.9	52.4	9.5	9.5	14.3	9.5	42.9	14.3	14.3	4.8	100.0

^*– adenoma; § – duodenal; + – colonic; wt – wildtype; - – deletions; + – insertions; neg.- negative, no analyzable signal