Table 1B. Frameshift analysis of coding microsatellites in MLH1−/−−derived NHL.
cMS Marker | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sample | APC | Tmem60 | Senp6 | Phactr4 | Mdm2 | Mdc1 | Casc3 | SDCCAG1 | Rasal2 | Tcf7l2 | Bend5 | NKtr1 | Rfc3 |
#1 (duodenal) | wt | wt/-1 | wt | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt | wt/-1 |
#2 (duodenal) | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 |
#3 (thymus) | wt | wt | wt/-1 | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 |
#3 (spleen) | wt | wt | wt/-1 | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 |
#3 (kidney) | wt | wt | wt/-1 | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt | wt/-1 |
#3 (liver) | wt | wt | wt/-1 | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 |
#4 (thymus) | wt/-1 | wt | wt/-1 | wt | wt | wt | wt/-1 | wt | wt | wt | wt | wt | -1 |
#4 (spleen) | wt/-1 | wt/-1 | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt | -1/-2 |
#4 (liver) | wt/-1 | wt/-1 | wt | wt | wt | wt | wt/-1 | wt/-1 | wt | wt | wt | wt | -1 |
#5 (spleen) | wt/-1 | wt/-1 | wt | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt/-1 | wt/-1 |
#6 (liver) | wt | wt/-1 | wt | wt | neg. | wt | wt | wt | wt | wt | wt | wt/-1 | wt/-1 |
#7 (spleen) | wt | -2 | wt | wt | neg. | wt | wt | wt | wt/-1 | wt | wt | wt/-1 | wt/-1 |
#8 (spleen) | wt | wt | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt | wt | wt/-1 |
#9 (kidney) | wt | wt/-1 | wt | wt/+1 | wt | wt | wt/-1 | wt | wt | wt | wt | wt | wt/-1 |
#10 (spleen) | wt | wt/-1 | wt | wt | wt/-1 | wt | wt | wt | wt/-1 | wt | wt | wt | wt/-1 |
#10 (liver) | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 |
#10 (skin) | wt | wt/-1 | wt | wt | wt/-1 | wt | wt | wt | wt/-1 | wt | wt | wt | wt/-1 |
#11 (thymus) | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt | wt/-1 |
#11 (spleen) | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt | -1/-2 |
#11 (liver) | wt | wt | wt | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt | -1/-2 |
#1 (duodenal) | wt | wt/-1 | wt | wt | wt | wt | wt | wt | wt/-1 | wt | wt | wt | wt/-1 |
frequency [n] | 4/21 | 10/21 | 5/21 | 1/21 | 4/21 | 0/21 | 3/21 | 2/21 | 10/21 | 0/21 | 0/21 | 3/21 | 21/21 |
frequency [%] | 19.0 | 48.0 | 24.0 | 4.8 | 19.0 | 0.0 | 14.3 | 9.5 | 48.0 | 0.0 | 0.0 | 14.3 | 100.0 |
wt – wildtype; - – deletions; + – insertions; neg.- negative, no analyzable signal