Table 2B. Mutational profile of coding mono- and dinucleotide repeats in candidate target genes of MLH1-/- tumors. Comparison between primary GIT, allograft and allograft-derived cell line.
| cMS Marker | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample | APC | Tmem60 | Senp6 | Rasal2 | Tcf7l2 | Bend5 | NKtr1 | Rfc3 | Supt16 | C8a | Taf1b | Lig4 | Ptpn21 |
| primary | wt/-1 | wt | -1 | wt | wt | wt/-1 | wt | wt/-1 | wt | wt | wt | wt | wt |
| allograft | wt/-1 | wt | wt/-1 | wt/-1 | wt | wt/-1/-2 | wt/-1 | wt/-1 | -1 | MSI | wt/-1 | wt/-1 | wt |
| cell line | wt/-1 | wt | wt/-1 | wt | wt/-1 | wt/-1 | -1 | wt/-1 | wt | MSI | -1 | wt/-1 | wt/-1 |
wt – wildtype; MSI – microsatellite instable