Table 1. Expression of glutamine metabolism-related proteins according to the histologic subtype of thyroid cancer.
| Parameters | Total N= 557(%) |
PTC n= 344(%) |
FC n= 112(%) |
MC n= 70(%) |
PDC n= 23(%) |
AC n= 8(%) |
p-value |
|---|---|---|---|---|---|---|---|
| GLS1 (T) | <0.001 | ||||||
| Negative | 247 (44.3) | 141 (41.0) | 70 (62.5) | 27 (38.6) | 9 (39.1) | 0 (0.0) | |
| Positive | 310 (55.7) | 203 (59.0) | 42 (37.5) | 43 (61.4) | 14 (60.9) | 8 (100.0) | |
| GLS1 (S) | <0.001 | ||||||
| Negative | 554 (99.5) | 344 (100.0) | 112 (100.0) | 70 (100.0) | 23 (100.0) | 5 (62.5) | |
| Positive | 3 (0.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (37.5) | |
| GDH (T) | <0.001 | ||||||
| Negative | 105 (18.9) | 43 (12.5) | 48 (42.9) | 11 (15.7) | 3 (13.0) | 0 (0.0) | |
| Positive | 452 (81.1) | 301 (87.5) | 64 (57.1) | 59 (84.3) | 20 (87.0) | 8 (100.0) | |
| GDH (S) | <0.001 | ||||||
| Negative | 549 (98.6) | 341 (99.1) | 112 (100.0) | 70 (100.0) | 22 (95.7) | 4 (50.0) | |
| Positive | 8 (1.4) | 3 (0.9) | 0 (0.0) | 0 (0.0) | 1 (4.3) | 4 (50.0) | |
| ASCT2 (T) | <0.001 | ||||||
| Negative | 459 (82.4) | 289 (84.0) | 103 (92.0) | 43 (61.4) | 17 (73.9) | 7 (87.5) | |
| Positive | 98 (17.6) | 55 (16.0) | 9 (8.0) | 27 (38.6) | 6 (26.1) | 1 (12.5) |
PTC; papillary thyroid carcinoma, FC; follicular carcinoma, MC; medullary carcinoma, PDC; poorly differentiated carcinoma, AC; anaplastic carcinoma, GLS1; glutaminase 1, GDH; glutamate dehydrogenase, ASCT2; amino acid transporter-2