Table 3. Expression of glutamine metabolism-related proteins according to the histologic subtype and BRAF V600E mutation status of papillary thyroid carcinoma.
| Parameters | Total N=344 (%) |
Histologic subtype | p-value | BRAF V600E mutation status | p-value | ||
|---|---|---|---|---|---|---|---|
| Conventional type n= 304 (%) |
Follicular variant n= 40 (%) |
No mutation n= 106 (%) |
Mutation n= 238 (%) |
||||
| GLS1 (T) | 0.024 | <0.001 | |||||
| Negative | 141 (41.0) | 118 (38.8) | 23 (57.5) | 58 (54.7) | 83 (34.9) | ||
| Positive | 203 (59.0) | 186 (61.2) | 17 (42.5) | 48 (45.3) | 155 (65.1) | ||
| GDH (T) | <0.001 | <0.001 | |||||
| Negative | 43 (12.5) | 28 (9.2) | 15 (37.5) | 26 (24.5) | 17 (7.1) | ||
| Positive | 301 (87.5) | 276 (90.8) | 25 (62.5) | 80 (75.5) | 221 (92.9) | ||
| GDH (S) | 1.000 | 0.246 | |||||
| Negative | 341 (99.1) | 301 (99.0) | 40 (100.0) | 106 (100.0) | 235 (98.7) | ||
| Positive | 3 (0.9) | 3 (1.0) | 0 (0.0) | 0 (0.0) | 3 (1.3) | ||
| ASCT2 (T) | 0.041 | <0.001 | |||||
| Negative | 289 (84.0) | 251 (82.6) | 38 (95.0) | 102 (96.2) | 187 (78.6) | ||
| Positive | 55 (16.0) | 53 (17.4) | 2 (5.0) | 4 (3.8) | 51 (21.4) | ||
GLS1; glutaminase 1, GDH; glutamate dehydrogenase, ASCT2; amino acid transporter-2