Table 6. Univariate analysis of the influence of glutamine-related protein expression in thyroid cancer on disease-free and overall survival by the log-rank test.
| Parameter | Number of patients*/recurrence/death | Disease-free survival | Overall survival | ||
|---|---|---|---|---|---|
| Mean survival (95% CI) months |
P-value | Mean survival (95% CI) months |
P-value | ||
| GLS1 (T) | 0.141 | 0.938 | |||
| Negative | 247/22/13 | 101 (98-105) | 106 (103-108) | ||
| Positive | 302/17/17 | 106 (103-108) | 106 (103-108) | ||
| GDH (T) | 0.470 | 0.896 | |||
| Negative | 105/9/5 | 101 (96-107) | 106 (103-110) | ||
| Positive | 444/30/25 | 104 (102-107) | 106 (104-108) | ||
| GDH (S) | 0.110 | <0.001 | |||
| Negative | 545/38/28 | 104 (102-106) | 107 (105-108) | ||
| Positive | 4/1/2 | 68 (24-112) | 54 (13-95) | ||
| ASCT2 (T) | 0.677 | 0.217 | |||
| Negative | 452/33/22 | 104 (101-106) | 107 (105-109) | ||
| Positive | 97/6/8 | 103 (98-108) | 102 (96-107) | ||
*
cases of AC were excluded. GLS1; glutaminase 1, GDH; glutamate dehydrogenase, ASCT2; amino acid transporter-2