Table 2. Associations between patient characteristics and disease-specific and overall survival.
| Stage I-III | Stage IV | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | Disease-Specific Survival | Overall Survival | Disease-Specific Survival | Overall Survival | ||||
| 5-Year Rate |
HR (95% CI)* | 5-Year Rate |
HR (95% CI)* | Median, months | HR (95% CI)* | Median, months | HR (95% CI)* | |
| Sex | ||||||||
| Male | 0.73 | 1 (reference) | 0.59 | 1 (reference) | 16 | 1 (reference) | 14 | 1 (reference) |
| Female | 0.75 | 0.87 (0.84, 0.89) | 0.65 | 0.78 (0.77, 0.80) | 16 | 0.97 (0.94, 1.01) | 14 | 0.96 (0.93, 0.99) |
| P value* | <0.001 | <0.001 | 0.16 | 0.019 | ||||
| Age, years | ||||||||
| 18-44 | 0.80 | 0.44 (0.41, 0.47) | 0.77 | 0.27 (0.26, 0.29) | 17 | 0.74 (0.69, 0.80) | 16 | 0.67 (0.63, 0.72) |
| 45-54 | 0.81 | 0.44 (0.42, 0.46) | 0.77 | 0.28 (0.27, 0.29) | 18 | 0.70 (0.66, 0.74) | 17 | 0.64 (0.60, 0.67) |
| 55-64 | 0.79 | 0.50 (0.48, 0.52) | 0.72 | 0.36 (0.35, 0.37) | 17 | 0.77 (0.73, 0.81) | 15 | 0.73 (0.69, 0.77) |
| 65-74 | 0.75 | 0.61 (0.59, 0.63) | 0.62 | 0.53 (0.52, 0.54) | 15 | 0.87 (0.83, 0.92) | 13 | 0.85 (0.81, 0.89) |
| 75 and older | 0.64 | 1 (reference) | 0.43 | 1 (reference) | 14 | 1 (reference) | 11 | 1 (reference) |
| P value* | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Ethnicity/Race | ||||||||
| White | 0.75 | 1 (reference) | 0.62 | 1 (reference) | 16 | 1 (reference) | 14 | 1 (reference) |
| African American | 0.69 | 1.30 (1.24, 1.37) | 0.56 | 1.23 (1.18, 1.27) | 15 | 1.14 (1.08, 1.22) | 13 | 1.15 (1.09, 1.22) |
| Asian | 0.75 | 0.93 (0.88, 0.99) | 0.65 | 0.88 (0.84, 0.92) | 16 | 0.95 (0.88, 1.03) | 14 | 0.98 (0.91, 1.05) |
| Hispanic | 0.72 | 1.10 (1.05, 1.16) | 0.61 | 1.02 (0.98, 1.06) | 17 | 0.97 (0.91, 1.04) | 14 | 0.99 (0.93, 1.05) |
| Native American | 0.69 | 1.10 (0.89, 1.36) | 0.55 | 1.18 (1.00, 1.38) | 17 | 0.88 (0.70, 1.11) | 15 | 0.86 (0.70, 1.07) |
| P value* | <0.001 | <0.001 | <0.001 | <0.001 | ||||
*
Based on the multivariable Cox proportional hazards regression model adjusting for the variables included in the table and histology, differentiation, T stage, N stage, AJCC TNM7 stage (for stage I-III), surgery, radiation therapy, sequence of radiation to surgery, chemotherapy, number of lymph nodes resected, CEA level, year of diagnosis, marital status at diagnosis, and stratified by SEER registration sites.