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. 2016 Jul 20;7(33):53679–53701. doi: 10.18632/oncotarget.10725

Figure 1. IK6 is highly expressed in adult BCR-ABL1-positive B-ALL patients.

Figure 1

Figure 1

A. Schematic diagram of the full-length IKZF1 cDNA and the different isoforms detected in our samples. F: N-terminal zinc-fingers show DNA-binding activity, and C-terminal zinc fingers mediate dimerization of the protein. Ex indicates exon. B. Expressions of the different IKZF1 isoforms in 42 BCR-ABL1-positive B-ALLsamples were determined by RT-PCR. IK1(945bp), IK2(884bp), IK4 (458bp), IK6(255bp). C. Sequencing analysis of IK6 isoform in which exon 3 is juxtaposed with exon8. D. Kaplan-meier estimation of DFS in IK6-positive and -negative group. E. Cumulative incidence of relapse curves by IKZF1 status in our samples, with 3-year estimates. CR1, first complete remission.