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. 2016 Jul 20;7(33):53679–53701. doi: 10.18632/oncotarget.10725

Table 2. Patients’ characteristics.

Clinical parameter IK6-positive IK6-negative P value
(n=20) (n=22)
N % N %
Gender
Male 11 55 13 59.1 0.789
Female 9 45 9 40.9
Age(years)
18-39 10 50 12 54.5 0.918
40-64 6 30 7 31.8
≥65 4 20 3 13.6
White blood cells count (cells×109/L)
<30 4 20 15 68.2 0.005
30-100 6 30 4 18.2
>100 10 50 3 13.7
aEarly clinical response
Yes 6 30 15 68.2 0.013
No 14 70 7 31.8
BCR-ABL1
p190 11 55 14 63.6 0.569
p210 9 45 8 36.4
Imatinib exposure
Yes 13 65 16 72.7
No 7 35 6 27.3
bHSCT
Yes 4 20 7 31.8
No 16 80 15 68.2
cMRD risk group
Standard risk 4 20 12 54.5 0.036
Intermediate risk 9 45 8 36.4
High risk 7 35 2 9.1
a

Early clinical response was defined as≤5% leukemic blast cells in the bone marrow at day 21 (depending on national induction protocols).

b

HSCT, hematopoietic stem cell transplantation.

c

Minimal residual disease (MRD), standard risk: negative after induction therapy on treatment day 33 and consolidation therapy on treatment day 78, high risk: still positive at an MRD level of ≥103 after consolidation therapy on treatment day 78, intermediate risk: all others.