Figure 2. Memantine inhibits K_v1.3 channel currents of human T cells.

A. and B. The dose response relationship for memantine is shown for isolated K_v1.3 currents recorded from A. resting and CD3 Ab-activated (24 h) human CD3⁺ cells and B. naïve and memory CD4⁺ T cells isolated from peripheral blood of healthy donors. Data points represent mean values ± SEM calculated from 4-5 cells per experiment. A, n=5; B, n=4 experiments.