Table 3. Risk factors evaluated for the influence on severe pneumonia.
| Factor | Severe pneumonia | No severe pneumonia | OR (95% CI) | P |
|---|---|---|---|---|
| (N=16) | (n=52) | |||
| N (%) | N (%) | |||
| Age · Years | ||||
| <28 | 7 (43.8) | 23 (44.2) | 1.0 | |
| ≥28 | 9 (56.3) | 29 (55.8) | 1.02 (0.33-3.15) | 0.973 |
| Gender | ||||
| Female | 4 (25.0) | 21 (40.4) | 1.0 | |
| Male | 12 (75.0) | 31 (59.6) | 2.03 (0.58-7.16) | 0.270 |
| Underlying disease | ||||
| Acute myelocytic leukemia | 6 (37.5) | 31 (59.6) | 1.0 | |
| Acute lymphoblastic leukemia | 8 (50.0) | 17 (32.7) | 2.43 (0.72-8.17) | 0.151 |
| Chronic myelocytic leukemia | 1 (6.3) | 1 (1.9) | 5.17 (0.28-94.50) | 0.268 |
| Others | 1 (6.3) | 3 (5.8) | 1.72 (0.15-19.49) | 0.661 |
| Donor type | ||||
| Matched related | 12 (75.0) | 33 (63.5) | 1.0 | |
| Matched unrelated | 2 (12.5) | 11 (21.2) | 0.83 (0.19-3.52) | 0.795 |
| Mismatched related | 1 (6.3) | 4 (7.7) | 0.69 (0.07-6.78) | 0.748 |
| Mismatched unrelated | 1 (6.3) | 4 (7.7) | – | 0.999 |
| Stem cell source | ||||
| Bone marrow | 1 (6.3) | 7 (13.5) | 1.0 | |
| Peripheral blood | 11 (68.8) | 32 (61.5) | 2.41 (0.27-21.81) | 0.435 |
| Bone marrow and peripheral blood | 4 (25.0) | 13 (25.0) | 2.15 (0.20-23.18) | 0.527 |
| GVHD | ||||
| Acute GVHD Grade 0-2 | 7 (43.8) | 48 (92.3) | 1.0 | |
| Acute GVHD Grade 3-4 or Chronic GVHD | 9 (56.3) | 4 (7.7) | 15.43 (3.73-63.82) | <0.001 |
| Viral infection | ||||
| CMV/RSV mono-infection or no infection | 5 (31.3) | 45 (86.5) | 1.0 | |
| CMV and RSV co-infection | 11 (68.8) | 7 (13.5) | 14.14 (3.77-53.13) | <0.001 |
| Bacterial infectiona | ||||
| No | 11 (68.8) | 48 (92.3) | 1.0 | |
| Yes | 5 (31.3) | 4 (7.7) | 5.46 (1.26-23.70) | 0.024 |
a
Gram-negative bacillus and gram-positive coccus. Abbreviations: CMV, cytomegalovirus; RSV, respiratory syncytial virus; GVHD, graft vs host disease; OR, Odds ratio; CI, Confidence interval.