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In case of sustained Ca2+ increase and calcineurin activation, NFAT proteins shuttle into the nucleus where they accumulate on target promoter sites. DNAJB6 reduces TNF- α expression through interacting with NFATc3 and HDAC4, leading to the repression of calcineurin-induced cardiomyocyte hypertrophy. Note: → indicates promotion; ┤indicates inhibition.
