. 2016 Jun 9;7(33):54028–54050. doi: 10.18632/oncotarget.9927

Table 2. Pharmacogenomics studies by Affymetrix DMET™ Plus.

Drug	Disease	Phenotype	Sample size	Gene	SNP(s)	Reference
Warfarin	Cardiovascular disease	Clinical response	497	CYP4F2	rs2108622	[50]
Docetaxel and/or Thalidomide Docetaxel	Prostate cancer Gynecological cancer	Clinical response Toxicity Neutropenia	47 42	PPAR-γ SULT1C2 CHST3 SPG7 CYP2D6 NAT2 ABCC6 ATP7 CYP4B1 SLC10A2 CYP39A1	rs2016520^a, rs1883322^a rs3734254^a, rs7769719^a rs6922548 rs1402467 rs4148943, rs4148947, rs12418, rs730720 rs2292954, rs12960 rs72549353 rs1799931 rs2238472 rs2227291 rs4646487 rs2301159 rs7761731	[57] [58]
Clopidogrel	Cardiovascular disease	Clinical response Clinical outcome	162 2932	CYP2C19 ABCB1	rs4244285 rs1045642	[59] [61]
Irinotecan	Colorectal cancer	Gastrointestinal toxicity	26	ABCC5 ABCG1 SCLO1B1	rs562 rs425215 rs2306283	[66]
Zoledronic acid	Multiple Myeloma	Osteonecrosis of the jaw	19	PPARG ABP1 CHST11 CROT	rs1152003 rs10983, rs4725373, rs1049793 rs2463437, rs903247, rs2468110 rs2097937	[68]
Erlotinib	Advanced Non Small Lung cancer	Skin rush	34	CYP27B1 MAT1A CHST11 ADH6 CYP4B1	rs8176345 rs9285726 rs903247, rs2468110 rs6830685 rs2297809	[84]
5-Fluorouracil	Colorectal cancer	Toxicity	24	CHST1 GSTM3	rs9787901 rs1799735	[85]
Telmisartan	Hypertension	Pharmacokinetics	33	UGT1A1 UTG1A3	rs4148323, rs8175347 rs3806596, rs45625338	[86]
Paclitaxel	Breast cancer Solid tumors	Peripheral neuropathy Clearance	209 412 270	CYP2C8 CYP2C8 ABCG1 SLC22A11 GSTZ1 SLC28A2 VKORC1 PGAP3 CDA EPHX1 CYP20A1 SLC6A6 CRIP3 GSTA4 AKAP9 CYP51A1 CYP2D7P1	rs10509681 rs10509681 rs492338 rs1783811 rs7975 rs1060896 rs9923231 rs2952151 rs1048977 rs1051740 rs1048013 rs2341970 rs2242416 rs13197674 rs7785971 rs7797834 rs28360521	[87] [88] [89]
Fludarabine-Cytarabine-Idarubicin	Acute Myeloid Leukemia	Clinical response Toxicity	94	ADH1A SULT2B1 SLC22A12 CYP2E1 SLCO1B1	rs6811453, rs1826909 rs2302948 rs11231825 rs2070673, rs2515641 rs4149056	[92]
Ara-C-daunorobucin-etoposide-mitoxantrone	Acute Myeloid Leukemia	Overall survival	164	SLCO1B1	rs2291075	[93]
Daunorubicin	Hematological cancers	Clearance	107	FMO3 GSTP1	rs2266782 rs1695	[94]
Aspirin	Cerebrovascular disease	Small bowel bleeding	25	CYP2D6 CYP4F11	rs28360521 rs1060463	[95]
Aspirin	Cardiovascular disease	Peptic ulcer Ulcer bleeding	593	SLCO1B1 CHST2	rs4149056 rs6664	[97]
Busulfan	Hematological cancers	Clearance	65	GSTA5	rs4715354, rs7746993	[98]

Results are from analyses restricted to docetaxel and thalidomide trial arm