Table 3.
Frequency of spatial patterns (R = random distribution, reg = regular or uniform distribution, reg clusters = regularly distributed clusters of inclusions) of the tau-immunoreactive neurofibrillary tangles (NFT) and neuritic plaques (NP) in the cerebral cortex and hippocampus in seven cases of Alzheimer’s disease neuropathologic change (ADNC) without CTE
| Pathology | Region | R | Reg | Reg clusters | Large clusters |
|---|---|---|---|---|---|
| NFT | Cortex | 1 | 0 | 22 (12) | 7 |
| Sub/HC/DG | 3 | 0 | 9 (0) | 1 | |
| NP | Cortex | 1 | 1 | 12 (8) | 12 |
| Sub/HC/DG | 3 | 1 | 11 (0) | 5 |
Figures in parentheses in column 5 indicate percentage of regions investigated in which cluster size was in the range 400–800 µm
Chi-square (χ2) contingency tests: CTE vs ADNC NFT χ2 = 19.29 (3DF, P > 0.001) and NP χ2 = 9.80 (3DF, P < 0.05)