Table 1.
Baseline characteristics of patients with cSVD and controls.
| cSVD | Controls | p-Valuec | |
|---|---|---|---|
| (n = 73) | (n = 39) | ||
| Age, y, mean(SD) | 70(11) | 69(12) | 0.49 |
| Male, n(%) | 43(59) | 23(59) | 0.99 |
| Hypertension, n(%) | 46(42) | 18(46) | 0.09 |
| Hypercholesterolemia, n(%) | 47(64) | 13(33) | < 0.01 |
| Diabetes Mellitus, n(%) | 12(16) | 4(10) | 0.57 |
| Smoking, n(%) | 18(25) | 3(7.7) | 0.04 |
| Body mass index, mean(SD) | 25(3.9) | 27(3.5) | 0.04 |
| Educationa | 0.26 | ||
| High, n(%) | 13(18) | 6(15) | |
| Moderate, n(%) | 26(36) | 20(51) | |
| Low, n(%) | 34(47) | 13(33) | |
| Calcium antagonists intake (n%) | 14(19) | 4(10) | 0.29 |
| WMH load, mean (SD) × 10− 3 | 14(15) | 5.0(9.8) | < 0.001 |
| Presence of severe PVSb | |||
| Centrum semiovale n(%) | 30(48) | 13(37) | 0.32 |
| Basal ganglia n(%) | 17(27) | 2(5.1) | 0.02 |
Abbreviations: WMH = white matter hyperintensity; PVS = perivascular spaces.
Bold values indicate significance at p < 0.05.
a
Education level: low: finished high school or lower; moderate: finished intermediate vocational education; high: finished university degree (Verhage, 1964).
b
These values represent participants with > 25 PVS (Appendix 1.3).
c
t-Test or chi-square.