Table 2.
Perfusion volume fraction f and parenchymal diffusivity D of patients and controls.
| cSVD (n = 73) | Controls (n = 39) | Model 1a ΔMean(95% CI)d |
p-Value | Model 2b β(95% CI)e |
p-Value | R2 | |
|---|---|---|---|---|---|---|---|
| Perfusion volume fraction f × 10− 2 (SE) | |||||||
| NAWM | 2.31(0.03) | 2.21(0.03) | 0.11(0.03, 0.20) | 0.011c | 0.48(0.08, 0.88) | 0.020c | 0.197 |
| DGM | 2.95(0.04) | 2.69(0.05) | 0.26(0.12, 0.39) | < 0.001c | 0.68(0.29, 1.07) | 0.001c | 0.247 |
| Cortex | 2.53(0.04) | 2.40(0.04) | 0.14(0.02, 0.26) | 0.024c | 0.39(− 0.02, 0.79) | 0.060 | 0.184 |
| WMHs | 3.21(0.04) | 3.03(0.09) | 0.19(0.02, 0.39) | 0.076 | 0.38(− 0.03, 0.78) | 0.068 | 0.158 |
| Parenchymal diffusivity D × 10− 4 (SE) mm2/s | |||||||
| NAWM | 7.35(0.04) | 7.15(0.05) | 0.20(0.08, 0.32) | 0.002c | 0.56(0.18, 0.93) | 0.004c | 0.325 |
| DGM | 7.77(0.05) | 7.54(0.05) | 0.24(0.08, 0.39) | 0.003c | 0.44(0.07, 0.82) | 0.020c | 0.329 |
| Cortex | 7.40(0.02) | 7.30(0.03) | 0.10(0.02, 0.18) | 0.012c | 0.45(0.04, 0.86) | 0.030c | 0.191 |
| WMHs | 9.38(0.11) | 8.93(0.19) | 0.45(0.04, 0.86) | 0.031c | 0.50(0.11, 0.88) | 0.012c | 0.264 |
NAWM = normal appearing white matter; DGM = deep grey matter; WMHs = white matter hyperintensities; SE = standard error; CI = confidence interval; R2 = R-squared of the linear regression model.
a
Unadjusted Student's t-test.
b
Linear regression adjusted for age, sex, and cardiovascular factors.
c
Remained significant after testing for multiple comparisons.
d
ΔMean refers to the differences in mean of the IVIM parameter between the cSVD and control group.
e
β is the regression coefficient of the independent variable group (0 = control; 1 = cSVD) in the multivariable regression model.