Table 3.

Association of perfusion volume fraction f and parenchymal diffusivity D with the WMH load in patients with cSVD.

	Model 1a β(95% CI)c	p-Value	R2	Model 2b β(95% CI)c	p-Value	R2
Perfusion volume fraction f
NAWM	1.89(0.51, 3.27)	< 0.01	0.095	1.49(0.21, 2.78)	0.024	0.389
DGM	1.86(1.00, 2.72)	< 0.001	0.207	1.14(0.23, 2.05)	0.015	0.397
Cortex	1.58(0.57, 2.59)	< 0.01	0.121	1.19(0.25, 2.13)	0.014	0.398
WMHs	0.13(− 0.87, 1.13)	0.794	0.132	− 0.02(− 0.94, 0.91)	0.972	0.328
Parenchymal diffusivity D
NAWM	311(227, 395)	< 0.001	0.436	253 (153, 353)	< 0.001	0.529
DGM	221(155, 287)	< 0.001	0.384	178 (103,252)	< 0.001	0.513
Cortex	406 (273, 539)	< 0.001	0.342	302(162, 443)	< 0.001	0.488
WMHs	105 (78,132)	< 0.001	0.455	97 (66, 128)	< 0.001	0.588

NAWM = normal appearing white matter; DGM = deep grey matter; WMHs = white matter hyperintensities; CI = confidence interval; R² = R-squared of the linear regression model.

Bold values indicate significance at p < 0.05.

^aUnadjusted Student's t-test.

^bLinear regression adjusted for age, sex, and cardiovascular factors.

^cβ is the regression coefficient of the IVIM parameter (f or D) in the multivariable regression model where WMH load is the dependent variable.