Figure 3.

Potential therapeutical interventions targeting APP metabolites and its binding partners. Several strategies picking up on involvement of APP and its metabolites in pathophysiological mechanisms following acute insults are briefly portrayed. Depiction as a scale emphasizes the importance of balanced APP metabolism. Therapeutical strategies may employ either enhancement of neuroprotective action of APPsα such as block of LTCC and NMDAR or elevation of APPsα levels by activation of α-secretases or exogenous application. Other approaches might aim at mitigating harmful effects of amyloid ß either by inhibition of its production, prevention of deposition into plaques or facilitated degradation. These strategies might ameliorate acute damage as well as prevent further degeneration.