Table 2.
Study variables by child COMT genotype.
| Variable | Child COMT val158met Genotype | |||
|---|---|---|---|---|
| Study 1 (Stony Brook University)a | Study 2 (Western University)b | |||
| val/val (N = 73) | val/met + met/met (N =340) | val/val (N = 102) | val/met + met/met (N =260) | |
| M (SD) | M (SD) | M (SD) | M (SD) | |
| Anxiety | 11.09 (7.23)* | 9.19 (8.39)* | 9.66 (2.18)† | 9.02 (1.92)† |
| Depression | 5.12 (4.19)** | 3.89 (4.37)** | 13.21 (0.70)* | 12.65 (1.52)* |
| ODD | 5.36 (7.83) | 4.81 (6.74) | 13.44 (3.24) | 12.99 (3.12) |
| ADHD | 2.60 (6.19) | 2.75 (6.50) | 36.70 (9.22) | 35.79 (8.01) |
p < 0.10,
p < .05,
p < .01.
Mean ranks were tested using Wilcoxon rank sum test, as symptom scores were not normally distributed due to absence of internalizing symptoms in some children. These children received a score of ‘0’ on the relevant symptom sub-scale on the PAPA.
Symptom data based on maternal interview reports from the PAPA.
Primary caregiver reports from the ECI-4.
Note: N, sample size; SD, standard deviation; PPVT, Peabody Picture Vocabulary Test; SES, socioeconomic status as indexed by Hollingshead’s Four Factor Index of Social Status [Hollingshead, 1975]; PAPA, Preschool Age Psychiatric Assessment; ECI-4, Early Childhood Inventory-4 [Gadow and Sprafkin, 1997]; COMT, Catechol-O-methyltransferase; val, valine; met, methionine.