Table 2.
Significant results of the analysis of NGAL, BGN, MEK1, MEK2, HSP27, and YWHAZ SNPs and AO variation taking into account intrafamilial nonindependency
| Gene | SNP | Genotypes | B | 95% CI | P‐value |
|---|---|---|---|---|---|
| NGAL | rs3780836 | CC (reference) | – | – | – |
| CT | −6.07 | [−11.15; −0.98] | 0.019 | ||
| BGN (female group) | rs2269404 | CC (reference) | – | – | – |
| TT | 10.48 | [1.03; 19.93] | 0.030 | ||
| MEK1 | rs8039880 | AA (reference) | – | – | – |
| GG | −7.02 | [−14.03; 0.00] | 0.050 | ||
| rs11630608 | TT (reference) | – | – | – | |
| CC | −12.75 | [−20.98; −4.53] | 0.002 | ||
| CT | −9.38 | [−14.21; −4.55] | P < 0.001 | ||
| rs16949939 | CC (reference) | – | – | – | |
| CT | 26.15 | [14.34; 37.96] | P < 0.001 | ||
| rs745796 | TT (reference) | – | – | – | |
| CC | −10.49 | [−19.50; −1.47] | 0.023 | ||
| MEK2 | rs1823059 | CC (reference) | – | – | – |
| TT | 17.08 | [4.13; 30.03] | 0.010 | ||
| HSP27 | rs11769502 | CC (reference) | – | – | – |
| CT | −6.664 | [−11.30; −2.02] | 0.005 | ||
| YWHAZ | rs17365305 | GG (reference) | – | – | – |
| GA | −6.759 | [−12.97; −0.55] | 0.033 |
B, unstandardized coefficient (estimated quantitative effect of each genotype on AO variation compared with the reference genotype); CI, confidence interval; P‐value, significance level was set to 0.05.