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. 2016 Nov 16;117(2):646–654. doi: 10.1152/jn.00781.2016

Fig. 2.

Fig. 2.

Effect of acute dehydration on supraoptic nucleus (SON) polyol and vasopressin pathways in wild-type (WT) or fructokinase A/C knockout (KHK-KO) mice. Shown is the effect of acute water restriction (WR) on SON sorbitol levels (A), fructose levels (B), uric acid (C), aldose reductase (AR) mRNA expression (D), vasopressin mRNA (E), apelin mRNA (F), and TRPV1 mRNA (G). mRNA of target genes was normalized to the mRNA of two housekeeping genes, cyclophilin/β-actin. C: the effect of mouse strain was significant (between WT and KHK-KO, P < 0.01), and there was a significant interaction (P = 0.022) between the mouse strains (WT and KHK-KO) and dehydration conditions (control and WR) for uric acid. E: the effect of mouse strain was significant (between WT and KHK-KO, P < 0.01) for VP mRNA. Control, ad libitum. Values shown are means ± SE; n = 3 animals/group (A–C) and 4–5 animals/group (D–G). *P < 0.05. **P < 0.01. ***P < 0.001.