Fig. 2.

White-matter sparing around the injury epicenter at 7 days following a unilateral C4 contusion injury. A: summary of percent white matter spared, 1.6 mm around the injury epicenter in laminectomy (n = 4) and contusion (n = 4) groups. Evidence of significant white-matter compromise is present, 1 mm around the injury site (*P < 0.001). Spinal cord cross-section is a representative 20-μm-thick eriochrome cyanine stained section at the injury epicenter of a C4 contusion animal. Gray-shaded areas represent expected location of descending bulbospinal inputs to phrenic motoneurons in the ventromedial and lateral columns. B: summary of percent white matter spared in the ipsilateral-ventral columns, 1.6 mm around the injury epicenter in laminectomy (n = 4) and contusion (n = 4) groups (*P < 0.001, mixed linear model; post hoc Tukey-Kramer HSD at P < 0.05). The ipsilateral-ventral area quantified is highlighted in red in the spinal cord cross-section.