Table 2.
Initial values of mean arterial pressure (MAP, mmHg) and MAP changes induced by nifedipine and additional fasudil as well as MAP levels reached after inhibitors administration in WKY and SHR rats and HanSD and TGR animals as well as in SS/Jr or SR/Jr Dahl rats fed either LS or HS diet (Experiment 2).
| Strain | Number of rats | Initial MAP | Delta MAP nifedipine | MAP after nifedipine | Delta MAP additive fasudil | MAP after nifedipine + fasudil |
|---|---|---|---|---|---|---|
| SHR | 12 | 176 ± 2∗ | −64 ± 3∗ | 112 ± 3∗ | −43 ± 3 | 69 ± 2∗ |
| WKY | 9 | 110 ± 2 | −23 ± 1 | 87 ± 2 | −36 ± 2 | 52 ± 1 |
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| TGR | 11 | 162 ± 5∗ | −40 ± 8∗ | 122 ± 9∗ | −48 ± 5∗ | 75 ± 6 |
| HanSD | 12 | 116 ± 3 | −17 ± 2 | 102 ± 2 | −36 ± 2 | 66 ± 2 |
|
| ||||||
| SS/Jr-HS | 10 | 188 ± 5∗# | −89 ± 6∗# | 99 ± 4 | −30 ± 5 | 69 ± 5 |
| SS/Jr-LS | 6 | 142 ± 3∗ | −38 ± 4∗ | 104 ± 3 | −37 ± 4 | 68 ± 3 |
| SR/Jr-HS | 8 | 120 ± 3 | −24 ± 2 | 96 ± 3 | −36 ± 2 | 61 ± 1 |
| SR/Jr-LS | 8 | 121 ± 5 | −22 ± 3 | 99 ± 2 | −38 ± 2 | 62 ± 2 |
Data are means ± SEM. Significantly different (p < 0.05) ∗from the respective normotensive controls and #from the corresponding rat strain fed a low-salt diet.