Table 3.
Initial values of mean arterial pressure (MAP, mmHg) and MAP changes induced by acute RAS blockade (captopril 10 mg/kg) and additional SNS blockade (pentolinium 5 mg/kg) as well as MAP levels after captopril and pentolinium administration in spontaneously hypertensive rats (SHR) and Wistar-Kyoto controls (WKY), heterozygous Ren-2 transgenic rats (TGR), and Hannover Sprague Dawley controls (HanSD) as well as in salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) Dahl rats fed either a low-salt (LS) or high-salt (HS) diet (Experiment 3).
| Strain | Number of rats | Initial MAP | Delta MAP captopril | Delta MAP pentolinium |
Delta MAP captopril + pentolinium |
MAP after captopril + pentolinium |
|---|---|---|---|---|---|---|
| SHR | 7 | 176 ± 4∗ | −9 ± 3 | −88 ± 5∗ | −98 ± 6∗ | 78 ± 6∗ |
| WKY | 6 | 105 ± 3 | −6 ± 2 | −43 ± 6 | −49 ± 5 | 46 ± 1 |
|
| ||||||
| TGR | 7 | 175 ± 4∗ | −16 ± 1∗ | −81 ± 5∗ | −95 ± 5∗ | 83 ± 4∗ |
| HanSD | 7 | 120 ± 5 | −7 ± 3 | −45 ± 3 | −53 ± 5 | 70 ± 3 |
|
| ||||||
| SS/Jr-HS | 7 | 186 ± 7∗# | −18 ± 3∗# | −85 ± 8∗# | −103 ± 8∗# | 84 ± 5∗# |
| SS/Jr-LS | 7 | 140 ± 5∗ | −4 ± 2 | −66 ± 5 | −70 ± 5 | 70 ± 4∗ |
| SR/Jr-HS | 6 | 126 ± 7 | −4 ± 2 | −69 ± 7 | −73 ± 8 | 53 ± 2 |
| SR/Jr-LS | 7 | 117 ± 3 | −5 ± 1 | −58 ± 4 | −63 ± 4 | 54 ± 4 |
Data are means ± SEM. Significantly different (p < 0.05) ∗from the respective normotensive controls and #from the corresponding rat strain fed a low-salt diet.