(a).

Sigmoidal logistic model parameters	Dose-response curve to BAY K8644 before fasudil administration		Dose-response curve to BAY K8644 after fasudil administration		Two-way ANOVA p value
					Factor strain	Factor fasudil treatment
	SHR	WKY	SHR + fasudil	WKY + fasudil
max	128.2 ± 7.1∗	100.9 ± 3.0	69.7 ± 2.9∗#	38.5 ± 4.1#	<0.001	<0.001
log ED50	0.95 ± 0.06	0.88 ± 0.03	0.97 ± 0.04	0.96 ± 0.11	ns	ns
slope	1.54 ± 0.32	2.07 ± 0.31	2.68 ± 0.65	1.54 ± 0.67	ns	ns
	TGR	HanSD	TGR + fasudil	HanSD + fasudil
max	128.0 ± 6.5	114.0 ± 3.1	56.6 ± 4.0∗#	35.9 ± 2.5#	<0.001	<0.001
log ED50	1.12 ± 0.05	1.09 ± 0.03	1.10 ± 0.06	1.16 ± 0.06	ns	ns
slope	1.30 ± 0.17	1.48 ± 0.12	1.75 ± 0.40	1.83 ± 0.39	ns	ns