(b).
| Sigmoidal logistic model parameters | Dose-response curve to BAY K8644 before fasudil administration | Dose-response curve to BAY K8644 after fasudil administration | Two-way ANOVA p value |
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| Factor salt intake | Factor fasudil treatment | |||||
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| SS/Jr-HS | SS/Jr-LS | SS/Jr-HS + fasudil | SS/Jr-LS + fasudil | |||
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| max | 114.3 ± 3.2 | 115.4 ± 7.2 | 47.4 ± 4.3# | 56.9 ± 6.2# | ns | <0.001 |
| log ED50 | 0.94 ± 0.03 | 1.12 ± 0.06 | 1.00 ± 0.08 | 0.99 ± 0.11 | ns | ns |
| slope | 1.41 ± 0.13 | 1.32 ± 0.20 | 2.32 ± 0.87 | 1.71 ± 0.76 | ns | ns |
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| SR/Jr-HS | SR/Jr-LS | SR/Jr-HS + fasudil | SR/Jr-LS + fasudil | |||
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| max | 78.4 ± 3.3 | 81.9 ± 5.7 | 62.9 ± 15.2 | 77.0 ± 12.6 | ns | ns |
| log ED50 | 1.17 ± 0.04 | 1.27 ± 0.08 | 1.28 ± 0.20 | 1.40 ± 0.17 | ns | ns |
| slope | 1.26 ± 0.12 | 0.83 ± 0.08 | 1.25 ± 0.57 | 0.79 ± 0.17 | ns | ns |
Data are means ± SEM. max: maximal response (mmHg), log ED50: median effective dose (log dose µg/kg), and slope: slope of the dose-response curve (mmHg/ log dose µg/kg). Significantly different (p < 0.05) ∗from the respective normotensive controls and #from the corresponding rats measured before fasudil administration.