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Nrf1 directly regulates transcription of the ERAD machinery. Nrf1 ChIP-Seq binding sites in the promoters of the Ufd1l (A), Nploc4 (B), and VCP (C) genes are shown. (D) A manual ChIP-qPCR shows enrichment of Nrf1 at the Ufd1l, Nploc4, and VCP loci relative to the negative control, Txs. Error bars display the SEM (n = 3; *, P < 0.005).
