Table 2. Body composition parameters, drug dosing and clinical categories of thiopurine metabolites.
| 6TGN<235 | 235≤6TGN≤450 | 6TGN>450 | P value | |
|---|---|---|---|---|
| Mean±s.d. | ||||
| Weight (kg) | 75.7±18.1 | 75.8±17.7 | 72.4±17.4 | 0.96 |
| BMI (kg/m2) | 25.72±5.26 | 25.37±5.12 | 24.75±4.47 | 0.96 |
| BSA (m2) | 1.87±0.22 | 1.88±0.24 | 1.83±0.25 | 0.89 |
| Aza (mg; median (IQR)) | 150 (100–200) | 175 (144–213) | 150 (119–163) | 0.16 |
| Aza/weight (mg/kg) | 1.95±0.64 | 2.40±0.77 | 2.07±0.62 | 0.43 |
| Aza/FFM (mg/kg) | 3.10±1.39 | 3.62±1.08 | 3.13±1.01 | 0.30 |
| Aza/FM (mg/kg) | 6.88±2.80 | 9.51±6.64 | 8.29±6.94 | 0.64 |
| 6MP dose (mg; median (IQR)) | 50 (38–75) | 75 (50–106) | 50 (25–75) | 0.38 |
| 6MP/weight (mg/kg) | 0.74±0.18 | 1.03±0.31 | 0.79±0.68 | 0.22 |
| 6MP/FFM (mg/kg) | 1.26±0.34 | 1.63±0.58 | 1.40±1.17 | 0.63 |
| 6MP/FM (mg/kg) | 2.44±0.89 | 3.64±1.54 | 2.19±2.13 | 0.38 |
| (6MMP:6TGN)<20 | (6MMP:6TGN)>20 | P value | |
|---|---|---|---|
| Mean±s.d. | |||
| Weight (kg) | 75.9±18.0 | 70.3±14.0 | 0.59 |
| BMI (kg/m2) | 25.55±5.14 | 24.28±3.99 | 0.59 |
| BSA (m2) | 1.88±0.24 | 1.81±0.22 | 0.51 |
| Aza (mg; median (IQR)) | 150 (118–200) | 200 (175–200) | 0.03 |
| Aza/weight (mg/kg) | 2.09±0.72 | 2.68±0.45 | 0.02 |
| Aza/FFM (mg/kg) | 3.12±1.17 | 4.20±0.97 | 0.01 |
| Aza/FM (mg/kg) | 8.01±5.41 | 10.38±7.29 | 0.33 |
| 6MP dose (mg; median (IQR)) | 75 (50–75) | 62.5 (50–75) | 0.97 |
| 6MP/weight (mg/kg) | 0.89±0.34 | 1.12±0.06 | 0.29 |
| 6MP/FFM (mg/kg) | 1.47±0.60 | 1.69±0.42 | 0.62 |
| 6MP/FM (mg/kg) | 2.98±1.32 | 4.18±2.98 | 0.62 |
| 6MMP<5,700 | 6MMP>5,700 | P value | |
|---|---|---|---|
| Mean±s.d. | |||
| Weight (kg) | 76.9±17.6 | 65.4±14.3 | 0.09 |
| BMI (kg/m2) | 25.72±5.06 | 23.41±4.36 | 0.20 |
| BSA (m2) | 1.90±0.23 | 1.73±0.22 | 0.06 |
| Aza (mg; median (IQR)) | 150 (125–200) | 175 (150–200) | 0.36 |
| Aza/weight (mg/kg) | 2.10±0.72 | 2.64±0.50 | 0.05 |
| Aza/FFM (mg/kg) | 3.21±1.18 | 4.15±0.97 | 0.02 |
| Aza/FM (mg/kg) | 8.07±5.42 | 10.04±7.35 | 0.46 |
| 6MP dose (mg; median (IQR)) | 69.6±35.6 | 66.7±14.4 | 0.92 |
| 6MP/weight (mg/kg) | 0.87±0.35 | 1.13±0.05 | 0.15 |
| 6MP/FFM (mg/kg) | 1.44±0.61 | 1.76±0.32 | 0.36 |
| 6MP/FM (mg/kg) | 2.95±1.36 | 3.90±2.16 | 0.68 |
Aza, Azathioprine; BMI, body mass index; BSA, body surface area; FFM, fat-free mass; FM, fat mass; IQR, interquartile range; 6MP, 6-mercaptopurine; 6MMP, 6-methylmercaptopurine; 6TGN, 6-thioguanine nucleotide.