Table 5. Influence of genetic variations in COX-2/HPGD/SLCO2A1/ABCC4 on the time to recurrence of colorectal adenomas and crude risk of recurrence at 36, 60, and 120 months of follow-up.

		Recurrence (%)	aOR (95% CI)	aHR (95% CI)	Time to recurrencea (min–max)	Crude risk for recurrence (%)
						36 mo	60 mo	120 mo
Low-risk individuals
Global	–	46	–	–	112 (100–124)	2	21	86
SLCO2A1
rs9820625	AA/AC	32	10.71 (1.17–98.24)	3.33 (1.22–9.10)	115 (100–130)	3	16	70
	CC	80	–	–	85 (62–108)	0	29	100
ABCC4
rs9524821	GG/GA	41	–	2.93 (1.07–8.03)a	122 (97–147)	4	16	78
	AA	43	–	–	107 (57–157)	0	48	100
rs1678396	TT	50	–	0.20 (0.07–0.60)	94 (90–98)	0	18	100
	TC/CC	39	–	–	122 (95–149)	3	18	80
rs2274403	AA	50	–	0.26 (0.08–0.83)	85 (29–140)	0	44	69
	AG/GG	39	–	–	122 (109–135)	3	23	83
rs3742106	AA	21	5.36 (1.25–23.04)	5.78 (1.61–20.8)	135 (77–193)	0	8	72
	AC/CC	59			105 (84–126)	3	27	92
rs6492763	TT	73	0.18 (0.04–0.74)	0.26 (0.07–0.91)	93 (55–130)	6	38	100
	TC/CC	15	–	–	176 (−)	0	7	66
rs869951	GG/GC	35	–	–	114 (105–123)	3	17	89
	CC	75	–	–	66 (48–84)	0	50	100
High-risk individuals
Global		46	–	–	105 (87–123)	14	27	82
SLCO2A1
rs1131598	AA/AG	44	–	3.23 (1.49–7.02)	105 (86–124)	13	23	81
	GG	73	–	–	67 (59–74)	19	59	100
rs7616492	GG	57	–	–	94 (78–110)	14	40	94
	GA/AA	39	–	–	121 (98–143)	13	20	74
rs7340717	GG/GT	44	–	–	115 (88–142)	12	26	81
	TT	57	–	–	94 (43–145)	26	47	93
ABCC4
rs1678405	TT	39	2.09a (1.04–4.23)	1.75a (1.05–2.91)	109 (89–129)	7	22	77
	TC/CC	57	–	–	90 (76–104)	23	35	88

aOR, Odds ratio: logistic regression with center as covariate; aHazard Ratio, cox regression including center as covariate; CI, confidence interval; max, maximum; min, minimum; mo, month.

^aP>0.05 upon the bootstrap analysis based in 1,000 samples.