Table 5. Influence of genetic variations in COX-2/HPGD/SLCO2A1/ABCC4 on the time to recurrence of colorectal adenomas and crude risk of recurrence at 36, 60, and 120 months of follow-up.
Recurrence (%) | aOR (95% CI) | aHR (95% CI) | Time to recurrencea (min–max) |
Crude risk for recurrence (%) |
||||
---|---|---|---|---|---|---|---|---|
36 mo | 60 mo | 120 mo | ||||||
Low-risk individuals | ||||||||
Global | – | 46 | – | – | 112 (100–124) | 2 | 21 | 86 |
SLCO2A1 | ||||||||
rs9820625 | AA/AC | 32 | 10.71 (1.17–98.24) | 3.33 (1.22–9.10) | 115 (100–130) | 3 | 16 | 70 |
CC | 80 | – | – | 85 (62–108) | 0 | 29 | 100 | |
ABCC4 | ||||||||
rs9524821 | GG/GA | 41 | – | 2.93 (1.07–8.03)a | 122 (97–147) | 4 | 16 | 78 |
AA | 43 | – | – | 107 (57–157) | 0 | 48 | 100 | |
rs1678396 | TT | 50 | – | 0.20 (0.07–0.60) | 94 (90–98) | 0 | 18 | 100 |
TC/CC | 39 | – | – | 122 (95–149) | 3 | 18 | 80 | |
rs2274403 | AA | 50 | – | 0.26 (0.08–0.83) | 85 (29–140) | 0 | 44 | 69 |
AG/GG | 39 | – | – | 122 (109–135) | 3 | 23 | 83 | |
rs3742106 | AA | 21 | 5.36 (1.25–23.04) | 5.78 (1.61–20.8) | 135 (77–193) | 0 | 8 | 72 |
AC/CC | 59 | 105 (84–126) | 3 | 27 | 92 | |||
rs6492763 | TT | 73 | 0.18 (0.04–0.74) | 0.26 (0.07–0.91) | 93 (55–130) | 6 | 38 | 100 |
TC/CC | 15 | – | – | 176 (−) | 0 | 7 | 66 | |
rs869951 | GG/GC | 35 | – | – | 114 (105–123) | 3 | 17 | 89 |
CC | 75 | – | – | 66 (48–84) | 0 | 50 | 100 | |
High-risk individuals | ||||||||
Global | 46 | – | – | 105 (87–123) | 14 | 27 | 82 | |
SLCO2A1 | ||||||||
rs1131598 | AA/AG | 44 | – | 3.23 (1.49–7.02) | 105 (86–124) | 13 | 23 | 81 |
GG | 73 | – | – | 67 (59–74) | 19 | 59 | 100 | |
rs7616492 | GG | 57 | – | – | 94 (78–110) | 14 | 40 | 94 |
GA/AA | 39 | – | – | 121 (98–143) | 13 | 20 | 74 | |
rs7340717 | GG/GT | 44 | – | – | 115 (88–142) | 12 | 26 | 81 |
TT | 57 | – | – | 94 (43–145) | 26 | 47 | 93 | |
ABCC4 | ||||||||
rs1678405 | TT | 39 | 2.09a (1.04–4.23) | 1.75a (1.05–2.91) | 109 (89–129) | 7 | 22 | 77 |
TC/CC | 57 | – | – | 90 (76–104) | 23 | 35 | 88 |
aOR, Odds ratio: logistic regression with center as covariate; aHazard Ratio, cox regression including center as covariate; CI, confidence interval; max, maximum; min, minimum; mo, month.
P>0.05 upon the bootstrap analysis based in 1,000 samples.