Table 1. Characteristic of included studies.

NO	Study	Year	Country	Sample size	TP	TN	FP	FN	Cut-off value	Algorithm	Study type	Assay method	Kit used
1	Yu D	2015	China	123	57	46	7	13	Ct<45. 0	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
2	Jin P	2015	China	476	101	298	43	34	Ct<45. 0	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
3	He Q	2015	China	100	38	48	2	12	PMR≥ 4%	NA	Case–control	MethyLight	NA
4	He N	2015	China	281	54	196	9	22	Ct<40. 5	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
5	Wang Z	2012	China	56	25	18	2	11	PMR≥1%	NA	Case–control	MS-HRM	NA
6	Li SJ	2015	China	161	66	65	5	25	NA	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
7	Wu D	2016	China	1031	223	697	43	68	Ct<45. 0	1(1)	Prospective study	RT-PCR	Epipro Colon 2.0
8	Kang Q	2014	China	132	60	51	1	20	NA	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
9	Ding QQ	2015	China	262	60	171	9	22	Ct<45. 0	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
10	Warren JD	2011	US, Russia	144	38	93	1	12	Ct<45. 0	2(3)	Case–control	RT-PCR	Epipro Colon 1.0
		2011	USA, Russia	144	45	83	11	5	Ct<41. 0	1(3)	Case–control	RT-PCR	Epipro Colon 1.0
		2011	USA, Russia	144	35	94	0	15	Ct<45. 0	3(3)	Case–control	RT-PCR	Epipro Colon 1.0
11	Johnson DA	2014	USA	301	74	163	37	27	NA	NA	Prospective study	RT-PCR	Epipro Colon 1.0
12	Lee HS	2013	Korea	197	37	87	9	64	NA	1(3)	Case–control	RT-PCR	Abbott Molecular
13	Lucia PC	2014	USA	367	244	20	1	102	NA	NA	Case–control	RT-PCR	Epipro Colon 1.0
14	Marc T	2010	Germany	161	24	98	30	9	NA	2(3)	Case–control	Heavy MethyLight	NA
		2010	Germany	161	27	81	47	6	NA	1(3)	Case–control	Heavy MethyLight	NA
15	Grutzmann R	2008	Germany	831	193	403	50	185	NA	2(3)	Case–control	RT-PCR	Epipro Colon 1.0
16	deVos T	2009	Germany	514	138	282	45	49	3.4ug/L	1(3)	Case–control	RT-PCR	Epipro Colon 1.0
		2009	Germany	514	105	316	11	82	3.4ug/L	2(3)	Case–control	RT-PCR	Epipro Colon 1.0
17	Church TR	2013	Germany, USA	1510	27	1331	126	26	Ct<50	1(2)	Prospective study	RT-PCR	Epipro Colon 1.0
18	Toth K	2012	Hungary	184	73	91	1	19	Ct<40. 5	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
		2012	Hungary	184	88	78	14	4	Ct<40. 5	1(3)	Case–control	RT-PCR	Epipro Colon 2.0
19	Toth K	2014	Hungary	84	30	40	10	4	PMR≥ 0.01%	NA	Case–control	RT-PCR	Epipro Colon 2.0
20	Su XL	2014	China	234	152	58	4	20	MSP≥1%	NA	Case–control	MSP-DHPLC	NA
21	Potter NT	2014	USA	1544	30	1182	318	14	Ct<45. 0	1(3)	Prospective study	RT-PCR	Epipro Colon 2.0
22	Lofton-Day C	2008	USA	312	92	154	25	41	NA	NA	Case–control	MethyLight	NA
23	He Q	2010	China	352	136	164	6	46	PMR≥ 4%	NA	Case–control	MethyLight	NA
24	Ørntoft MW	2015	Denmark	470	93	282	60	35	Ct<45. 0	1(3)	Case–control	RT-PCR	Epipro Colon 2.0
		2015	Denmark	470	75	328	14	53	Ct<45. 0	2(3)	Case–control	RT-PCR	Epipro Colon 2.0
25	Ahlquist DA	2011	USA	100	18	54	16	12	Ct<45. 0	1(3)	Case–control	RT-PCR	Epipro Colon 1.0

MS-HRM, methylation sensitive high-resolution melting; MSP-DHPLC, methylation spective polymerase chain reaction; RT-PCR, real-time polymerase chain reaction.