Characteristics	PDB with GCT	PDB	GCT
Male: Female	2.1	1.2	F>M
Age of onset	>50	>60	20
Prevalence of polyostotic disease	93%	63%	Rare
Cardiovascular complications	More	Less	NA
Average number of affected sites	6.1±2.9	2.34±1.6	Single location in epiphysis of mature skeleton
Mortality rate (5 years)	50%	0-5%	Rarely due to disease
Response to antiresorptive therapy (bisphosphonates)	Poor	Good	Surgery is standard of treatment
Alkaline phosphatase	Elevated in almost 100% suggestive of active PDB	Elevated in active PDB	Normal

PDB: Paget’s disease of bone, GCT: Giant cell tumor