Table 2. Metabolite concentrations (mmol/kg_ww ± standard deviations) with statistical comparisons for a voxel in the ACC.

	ACC
	HC	MDD	Schizophrenia	P(HC-MDD)	P(HC-SZ)	P(MDD-SZ)
Glu	10.0 (1.3)	10.4 (0.7)	10.7 (1.2)	0.354	0.064	0.363
Gln	2.0 (0.5)	1.9 (0.7)	2.0 (1.0)	0.592	0.385	0.408
Gly	0.9 (0.3)	1.0 (0.2)	0.9 (0.2)	0.234	0.837	0.184
Gsh	1.3 (0.4)	1.2 (0.2)	1.4 (0.4)	0.334	0.303	0.060
Tau	1.6 (0.3)	1.6 (0.4)	1.7 (0.4)	0.671	0.484	0.284
Asp	2.8 (1.5)	2.1 (1.2)	2.9 (1.3)	0.134	0.925	0.128
Myo	8.0 (0.8)	7.2 (0.7)	8.4 (1.3)	0.009	0.327	0.002
Scy	0.5 (0.2)	0.4 (0.1)	0.6 (0.2)	0.026	0.406	0.004
Asc	1.1 (0.4)	1.1 (0.7)	1.4 (0.7)	0.984	0.237	0.249
TCH	2.4 (0.3)	2.4 (0.2)	2.4 (0.3)	0.805	0.792	0.625
TCR	8.9 (1.0)	8.9 (0.7)	9.5 (1.0)	0.929	0.052	0.075
TNAA	11.0 (1.4)	11.5 (0.6)	11.6 (0.8)	0.236	0.107	0.673

AC, anterior cingulate cortex; HC, healthy controls; MDD, major depressive disorder; SZ, schizophrenia; Glu, glutamate; Gln, glutamine; Gly, glycine; Gsh, glutathione; Tau, taurine; Asp, aspartate; Myo, myo-inositol; Scy, scyllo-inositol; Asc, ascorbate; TCH, total choline; TCR, total creatine; TNAA, total NAA. Bolded values indicate statistical significance (alpha<0.05/2, one-tailed, for Myo; alpha<0.05/3, two-tailed, for Scy).